TRP Channel Inhibitor

Zerencotrep (Standard) is the analytical standard of Zerencotrep (HY-101507). This product is intended for research and analytical applications. Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.

A-784168 (Standard) is the analytical standard of A-784168 (HY-108460). This product is intended for research and analytical applications. A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration.

9-Phenanthrol (Standard) is the analytical standard of 9-Phenanthrol. This product is intended for research and analytical applications. 9-Phenanthrol (9-Hydroxyphenanthrene) is a selective TRPM4 inhibitor with an IC50 of 17 μM. 9-Phenanthrol has no inhibitory activity on TRPM5, TRPC6, and CFTR. 9-Phenanthrol can be used for the research of ischemia-reperfusion injury.

TRPMPZQ-IN-1 (Compound 52) is a TRPM_PZQ inhibitor, with an EC₅₀ of 0.38 μM against TRPM_PZQ from Spirometra erinaceieuropaei. TRPMPZQ-IN-1 exhibits antiparasitic activity, showing an EC₅₀ of 4.3 μM against Echinococcus multilocularis. TRPMPZQ-IN-1 can be used in antiparasitic research.

TRPA1-IN-3 (commound 1) is a TRPA1 inhibitor. TRPA1-IN-3 can be used in skin and respiratory tract related research.

JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC₅₀ of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs.